Pakke Tiger Reserve, also known as Pakhui Tiger Reserve, is a Project Tiger reserve in the East Kameng district of Arunachal Pradesh in northeastern India. The 862 km2 (333 sq mi) reserve is protected by the Department of Environment and Forest of Arunachal Pradesh. In a notification (CWL/D/26/94/1393-1492) dated Itanagar 19 April 2001, issued by the Principal Secretary, the Governor of Arunachal Pradesh renamed Pakhui Wildlife Sanctuary as Pakke Wildlife Sanctuary Division.
This Tiger Reserve has won India Biodiversity Award 2016 in the category of 'Conservation of threatened species' for its Hornbill Nest Adoption Programme.
The area of Pakke Tiger Reserve was initially constituted as Pakhui Reserve Forest on 1 July 1966 and declared a game reserve on 28 March 1977. In 2001, it was renamed Pakhui Wildlife Sanctuary and became Pakhui Tiger Reserve on 23 April 2002 as the 26th Tiger Reserve under Project Tiger of the National Tiger Conservation Authority.